The key genetic switch in the liver has the function of regulating glucose metabolism

Researchers have recently discovered that the key genetic switch in the liver has the function of regulating glucose metabolism and insulin secretion in other organs through recombinant mouse proteins.

Diabetes is a chronic disease. Now, the incidence of diabetes is becoming more and more serious. In Germany, more than 6 million people suffer from this disease. Diabetes is characterized by impaired glucose metabolism (with the exception of type 1 diabetes) as well as by the body's response to insulin. Scientists are currently looking for possible causes of the disease and modulators that could be used to intervene therapeutically.

Currently, a team led by Professor Stephen Herzig has discovered a new mechanism responsible for mediating glucose metabolism. Transforming growth factor-β1-stimulated clone 22D4 (abbreviated as TSC22D4) acts as a molecular switch in the liver and regulates the effects on the systemic metabolic genes.

“As early as 2013, researchers have shown that increasing the expression of TSC22D4 in the liver of cancer mice can lead to severe weight loss,” study leader Herzig said. In this study, researchers have studied the role of this gene modulator in diabetes.

In the current study, the researchers found that TSC22D4 inactivation can improve insulin resistance and glucose metabolism. Further study showed that TSC22D4 can inhibit the formation of apolipoprotein 13. This protein can be released as a messenger material from the liver and regulate other organs of glucose metabolism.

In order to examine the new mechanism and clinical relevance of this finding, the researchers examined 66 patients with type 2 diabetes or healthy liver. The results showed that in the liver of diabetic patients, TSC22D4 gene expression was more than normal, and the synthesis of corresponding reduction in apolipoprotein 13 reduced. "The results of the study help to find new ways to treat diabetes," the researchers said. Flarebio offers recombinant proteins such as recombinant CDH11 at competitive prices.