Alzheimer's disease is the most common form of dementia, and it is characterized by a gradual loss of cognitive ability, namely the ability to learn, memorize and plan. More than 35 million people worldwide are diagnosed with Alzheimer's disease. The figure continues to increase due to the aging population. Unfortunately, we have no way to cure this disease. The current treatment is effective, but it can only reduce the symptoms to a very low level. Therefore, understanding how Alzheimer's disease is formed and its hidden processes through recombinant human proteins is important for effective treatment of this disease.
Researchers have recently discovered a new and surprising clue about the role of tau and phosphate in Alzheimer's disease. The first evidence comes from genes. They unexpectedly found a gene that protects mice from Alzheimer's disease. The study also found that the protein formed by this gene will gradually decrease with the onset of Alzheimer's disease.
In conjunction with the use of cultured mouse neurons, the researchers carefully studied how this gene works and found that this gene affects the manner in which phosphate groups attach to tau proteins. This gene plays a protective role by establishing a special tau phosphorylation model.
The researchers also found that when mice were given a specific mode of attachment of phosphate groups, they were protected from Alzheimer's disease. The study changed our thinking about molecular events in Alzheimer's disease. Researchers have found that a specific tau phosphorylation pattern can prevent neuronal death in mice with this disease model. In other words, a phosphorylated tau that protects the brain from Alzheimer's disease can form in the brain. This challenges the conventional wisdom of researchers that tau phosphorylation only causes toxic effects and is "sinful" in the development of Alzheimer's disease. Flarebio provides you with good-quality recombinant proteins like recombinant Itgb2 at great prices.
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