Overweight can lead to abnormal blood flow, resulting in multiple myeloma

A new study from the University of Washington's St. Louis School of Medicine shows that overweight can lead to abnormal blood flow and may lead to multiple myeloma. We know that overweight or obesity increases the risk of multiple myeloma, a plasma cell tumor that occurs in the blood and bone marrow, and that the disease occurs more often after the age of 60. Before the occurrence of multiple myeloma, patients often appear first known as MGUS blood abnormalities. This anomaly refers to that the plasma cells will produce a number of antibody proteins, and this pre-cancerous lesion generally shows no symptoms, so it is difficult to be diagnosed.

"Our study using recombinant human proteins found that obesity can be a risk factor for predicting multiple myeloma," said Dr. Su-Hsin Chang of the University of Washington. "If a patient is diagnosed with MGUS, normal body weight is likely to be a preventable development method of multiple myeloma."

The researchers analyzed data from 7,878 patients (mainly males) who were diagnosed with MGUS between October 1999 and December 2009, and these data were obtained from the American Legionnaire database. Among these subjects, 39.8% were overweight and 33.8% were obese. The researchers followed the group to see if they eventually developed multiple myeloma. Finally, the researchers found that 4.6% of overweight patients (the average follow-up time of about 5.75 years) and 4.3% of obese patients (average follow-up time of about 5.9 years) eventually developed into multiple myeloma, and normal weight patients were only 3.5 %. For multiple myeloma, the results were statistically different. Overweight MGUS patients and obese MGUS patients were 55% and 98% more than normal-weight patients to be likely to develop multiple myeloma.

MGUS patients have elevated levels of antibody M (IgM), while about 3% of people who were more than 50 would show IgM rise, so MGUS is difficult to diagnose and there is no very effective treatment. Multiple myeloma is the third largest blood tumor. According to the American Cancer Society, in 2016, it is expected to have 30330 new patients, and about 12650 patients will die of multiple myeloma.

Dr. Su-Hsin Chang saidm, "According to our findings, overweight and obesity are risk factors for MGUS development into multiple myeloma, and our overweight and obesity are human intervention. We hope that our research results will provide a new strategy for the treatment of our disease. Moreover, we will further study the mechanism of obesity in promoting the development of MGUS to multiple myeloma." Flarebio provides you with good-quality recombinant CDH2 at great prices.