Scientists find the link between DNA and chronic joint pain

Scientists at King's College London have discovered a link between DNA modification and chronic generalized joint pain, one of the main symptoms of fibromyalgia, and the study is funded by the Arthritis Research Foundation. Fibromyalgia is a common chronic condition that causes muscle and bone fatigue and widespread pain. Although fibromyalgia is very popular, the etiology is little understood, and the treatments are limited. What's worse, fibromyalgia can't be detected using routine tests such as scanning or X-ray detection. The disease affects 4% of the world. The study, published in the journal PLOS ONE which also has other studies on recombinant dog proteins, will help scientists develop a diagnosis of fibromyalgia through blood tests.

"Fibromyalgia is affected by genetic factors, but there are a number of complex intermediate processes between genes and diseases," said Frances Williams, Ph.D., one of the authors of the article from the Department of Twin and Genetic Epidemiology. "Identifying measurable epigenetic associations is an important step. What's more, these results will provide information on future studies of fibromyalgia and other chronic pain syndromes, such as irritable bowel syndrome."

Stephen Simpson, director of the British Arthritis Institute, commented on the study, "Millions of people in the UK suffer from fibromyalgia, and this exciting study has helped us understand how individuals' epigenetic differences affect fiber Myalgia and chronic extensive musculoskeletal pain. For people with long-standing fibromyalgia, they have been struggling to diagnose their pain symptoms. This study will help to better understand, manage and treatment joint pain."

The researchers used twins to study whether DNA methylation affects the way genes start up when they produce a particular protein and to observe whether there are differences between musculoskeletal pain patients and non-patients. Scientists have determined that patients with chronic extensive pain and non-patients have different levels of DNA methylation in the three genes. Preliminary indications suggest that people may have different methylation patterns in their DNA and that this may affect the initiation of some genes and may lead to a variety of conditions. Flarebio offers superior recombinant proteins including recombinant Ptpra at good prices.