2016年11月28日星期一

AIDS is no longer the nightmare for a lot of people

Researchers have made significant progress in developing highly-potent vaccines for preventing HIV infection by use of recombinant horse proteins. For the first time, researchers have shown that a combination of using a common cold virus to induce vaccination with and injecting DNA-based vaccines allows the immune system to proactively protect the human intestine and body cavity from HIV infection.

The results of the study are published in the journal Nature's Scientific Report. The results of this study represent an important step in the first line of defense for the introduction of HIV at the site of infection.

Dr. Branka Grubor-Bauk, a senior author at the University of Adelaide and at the Basil-Hazel Institute for Translational Health, Queen Elizabeth Hospital, said, "Sexual activity is one of the main methods of HIV transmission, thus it is necessary to protect those parts of the body that are most likely to encounter a virus. A possible cause of previous unsuccessful trials of HIV vaccines was the lack of first line protection.

"In mice, we injected a rhinovirus (or common cold virus) into its nose, and the virus changed parts that included the HIV protein. At the same time, DNA-based vaccines were also injected to mouse skin, which produces a very specific response in the immune system," Dr. Grubor-Bauk said. "Importantly, the vaccine works in two different immune systems: white blood cells which attack the HIV virus and specific antibodies which recognize and shut down HIV-positive cells."

Eric Gowans was responsible for the study, and he also worked in the surgical department at a university in the Basil Hetzel Institute. "HIV has the Tat effect, and one of the advantages of our vaccine approach is that antibodies can keep the Tat effect and prevent the propagation of the HIV virus," Gowans said.

"Overall, we found a significant reduction in the number of HIV-infected mice in our study. Our results now support further testing against HIV vaccines," he said. Flarebio offers recombinant proteins of good quality like recombinant CDH15 at great prices.

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