Scientists have found that Piezo2 protein prevents lung hyperproliferation in mice

Scientists have found through recombinant human proteins that Piezo2 protein prevents lung hyperproliferation in mice, according to a paper published online recently in the journal Nature. The findings will provide new insights into a number of respiratory disorders, such as sleep apnea and chronic obstructive pulmonary disease.

Most mammals prevent hyperproliferation of the lungs by a reaction known as the "He-Baum II reflex", which causes the inspiration to stop immediately. However, its specific working mechanism is not clear. Previously, no Piezo2 proteins were found associated with the respiratory system.

At this time, scientist Adam Patapatinian and his colleagues at the United States Scripps Institute explore the Piezo2 protein in regulating the role of lung expansion in mice. They found that deletion of the Piezo2 protein in adult mouse-specific neurons compromised the "He-Baum II reflex", resulting in increased tidal volume (i.e., greater intubation than usual), whereas neonatal mice lacking Piezo2 protein will die at birth.

These results show that Piezo2 protein can sense airway dilation, establish respiration in neonatal mice and regulate normal breathing in adult mice. This is essential for the initial expansion of the lung at birth.

The authors suggest that if the body of this expansion of the receptors defects, it will cause some respiratory disorder-related diseases, such as chronic obstructive pulmonary disease and sudden infant death syndrome. However, more detailed role of Piezo2 protein and the mechanism still needs further study. Flarebio offers good-quality recombinant proteins like recombinant TLR2 at competitive prices.