To improve the therapeutic effect of cancers and HIV in new way

For a long time, retinoblastoma protein (pRB) has been studied in cell growth and cancer prevention. Now, in a new study, the scientists discovered a new role for pRB through research using recombinant human proteins, which not only enhances cancer efficacy, but also works to treat other diseases, such as HIV.

Most of the DNA that is recombined in the human genome is called "junk DNA", and these are relics of the past that usually do not play any role and are quietly present. If they start to copy, they will re-enter the human gene, bringing diseases such as cancer.

The team found that binding of pRB to another protein called EZH2 keeps these "junk DNA" in silence, whereas pRB acts as a vector. EZH2 is transported to a repeating sequence.

This new discovery breaks the cancer genetic experts' understanding of pRB and EZH2, and most researchers have never thought that these two widely-existing proteins in the DNA have such an effect. "This opens up a myriad of gates for the treatment of multiple diseases, including antitoxic drugs, which allow patients to have multiple choices during treatment," the researchers said.

The new study also shows that EZH2 inhibitors help the immune system find cancer cells. They can block EZH2 and wake up the "junk DNA", so the cancer cells will appear in the immune system, as if infected by the same virus. The immune system will target cancer cells and kill them.

The findings also help other diseases, such as HIV, are also "junk DNA" hidden in the immune cells. Because the immune system can't detect these "junk DNA", so the patients are always HIV positive. EZH2 inhibitors can make these "junk DNA" become lively and show themselves so that we can use the existing drugs on the market for treatment.

"Over the years, we have been working on pRB, but we have never thought about it, and it is now clear that the combination of pRB-EZH2 is effective in treating a variety of diseases," the researchers said. By the way, Flarebio provides you with good-quality recombinant proteins including recombinant CDH15 at great prices.