Scientists reveal the relationship between intestinal microbes and β cells

Recently, researchers led by renowned biologist Professor Karen Guillemin at the University of Oregon have brought a great breakthrough in research. They found that growth division of β cells may be controlled by gut microbes. It is well known that β cells are the only cells capable of secreting insulin, and the importance of this finding is self-evident. It is reported that this is the first time that scientists revealed the relationship between intestinal microbes and β cells. The discovery may increase a weapon for the diagnosis and treatment of diabetes. This important study by Professor Guillemin's team has been published in the famous open-source journal eLife, which also publishes other studies on recombinant rat proteins.

Professor Guillemin's team has not yet carried out research in the human body, but they did a guided study. They found several intestinal micro-organisms in the human intestinal, and they can secrete protein like BefA protein with different similarity. Hill then treated the zebrafish with the highest and lowest similarities, and he was surprised to find that zebrafish β cells also returned to normal levels. This suggests that a similar phenomenon is most likely to occur in the human body. Professor Guillemin's team is currently conducting in-depth research.

"Our research suggests that the growth and development of animals may be dependent on the release of intestinal microbial signals," Hill said, "It is too excited to see that the intestinal microbial glucose stability in glucose plays such an important role."

"We have spent many years isolating and studying the intestinal flora of zebrafish, and our efforts have not been in vain," says Professor Guillemin. "We found BefA proteins that can regulate the growth of β cells."

For patients with type I diabetes, their onset time is very early. At that time, the β cells are very fragile and vulnerable to be attacked. If the corresponding micro-organisms are then missing, it will make the patient's condition worse. Incidence of type 1 diabetes includes genes and the environment, including environmental factors and intestinal micro-organisms. Studies have shown that human β-cells generally enter dormant period in the 5-year-old and stop the division of growth. Therefore, early use of antibiotics in newborns may increase the risk of newborns suffering from type I diabetes.

Professor Guillemin said that they currently need to work with researchers studying type 1 diabetes to study the development of BefA molecules as a potential therapeutic approach. There are already many companies in the development of microbial transplantation for the treatment of oral disease capsule, hoping that the treatment of diabetes can also use similar products. Flarebio provides you with high-quality recombinant proteins including recombinant CDH2 for your research.