The supplementation of folic acid can reduce the risk of chronic kidney disease

Through research using recombinant human proteins, Professor Hou Fanfan and Professor Xu Xin at Southern Medical University recently published a study in the Journal of Internal Medicine to first confirm that adequate supplementation of folic acid can significantly slow down the process of renal disease in patients with hypertension and reduce the risk of chronic kidney disease developing to uremia. Folic acid is cheap and easy to take and very safe, and it is suitable for high-risk groups as a means of prevention and treatment.

Chronic kidney disease has become a public health problem affecting 120 million people in China. Uremic patients can only rely on life-long dialysis or renal transplantation to survive, consuming huge medical resources. Chronic kidney disease patients also have a high risk of concurrent stroke and other cardiovascular and cerebrovascular events. Therefore, how to effectively delay the progress of chronic kidney disease and to prevent cardiovascular and cerebrovascular events have been the medical profession and the medical and health sector focus.

The study recruited more than 15,000 adult hypertensive patients from China's 20 rural communities to participate in the Chinese stroke primary prevention trial with an average age of 60 years. Patients were randomized to depressurization plus folic acid supplementation (10 mg of enalapril per day and 10 mg of enalapril per day) with an average duration of treatment of 4.4 year. The results showed that supplementation with folic acid significantly reduced the rate of renal dysfunction in hypertensive patients and reduced the risk of developing renal disease by 21% compared with antihypertensive therapy alone. In 1,671 patients with CKD prior to treatment, supplementation with folic acid reduced the risk of developing kidney disease by 56% and significantly reduced the risk of rapid renal impairment and the development and mortality of kidney disease.

It is understood that the lack of folic acid is very common in China, the average serum level was significantly lower than the Western population, which may be related to eating habits and genetic. In view of the importance of folic acid to human health, the United States and Canada have begun to add in cereals such as flour folic acid since 1998. China has not yet implemented a supplementary public health policy of folic acid, folic acid deficiency may also be a common cause of our population.

Epidemiological studies conducted early in the study showed that folic acid deficiency is a risk factor for the development of renal disease in Chinese rural communities. In response to this feature, the team conducted the above-mentioned folic acid supplementation delayed renal dysfunction in a randomized controlled study. The study also confirmed that supplementation of folic acid can effectively reduce the risk of stroke in patients with primary hypertension. Flarebio offers good-quality recombinant proteins like recombinant TLR2 at competitive prices.