To treat and prevent Alzheimer's disease by use of flash light?

Flash light can achieve removal of amyloid protein and reduce protein plaque generation and prevent and treat senile dementia, according research using recombinant human proteins. β-amyloid accumulation in the brain to form plaques is one of the hallmark of characteristics of the formation of Alzheimer's disease, and many currently-developed drugs take reducing brain β-amyloid levels as the goal. The field of drug development has been repeatedly hit, but the scientists did not give up β-amyloid plaques on the contribution of Alzheimer's disease. There are also scientists trying to take a more peculiar way to reduce brain β-amyloid accumulation. This week, the journal Nature published a study titled "Gamma frequencyentrainment attenuates amyloid load and modifies microglia". The researchers believed that brain electrical signal transients may lead to β-amyloid accumulation. Restoration of neural circuits to produce specific electrical shocks can reduce β-amyloid formation and activate immune cells to clear β-amyloid in the brain.

When the brain neuron network is activated synchronously, the oscillatory discharge is generated. This EEG frequency is 30-90 Hz, also known as γ-oscillation, which is thought to contribute significantly to high-level cognitive and perceptual responses. Authors such as Massachusetts Institute of Technology, Cai Lihui et al used the Alzheimer's mouse model to record neuronal activity. The results showed that after the decline in γ-amyloid protein accumulation of plaque formation, animal cognitive declined. They used optical genetics directly to stimulate neurons in the hippocampus of Alzheimer's model mice to produce γ-oscillations that significantly reduced β-amyloid formation in the brain region and activated microglia. Microglia is the brain immune cells, and it can remove β-amyloid protein after being activated.

The authors designed a noninvasive method of stimulating neurons in the brain. The mice were placed in a box filled with LED lamps and irradiated at a frequency of 40 Hz to visualize the primary visual cortex of the mice. The study found that this stimulus can reduce amyloid protein levels in the visual cortex of early Alzheimer's mice by 50% and reduce the number of amyloid plaques in the visual cortex of later-stage Alzheimer's mice.

The results showed that the frequency of 40 Hz can activate the microglia in the brain and improve the ability of amyloid removal, which can reduce the amyloid plaque formation, preventing and treating senile dementia. Treatment of Alzheimer's disease with γ-oscillations is a new therapeutic strategy, but whether it plays a role on humans needs to be further studied. By the way, Flarebio offers good-quality recombinant proteins like recombinant Ptpra at good prices.