Infections caused by clostridium difficile are quite difficult to deal with clinically. A new study shows that a small molecule containing selenium is expected to have effective treatment for this type of disease. Interestingly, this compound doesn’t kill bacteria as straightforward as antibiotics do, but makes toxins secreted by the bacteria become ineffective.
Clostridium difficile, also known as prismatic Bacillus difficile, can lead to pseudomembranous colitis, patients often accompanied by symptoms of diarrhea. In the US alone, there are dozens of people each year are caused by bacteria infection problems. Infection is usually caused by patients taking broad-spectrum antibiotics or chemotherapy broke normal intestinal microbial balance and lead. At present the main method of treating clostridium difficile infection is still in clinical use of antibiotics, but the effect is not ideal.
In recent years, a number of drug developers have come up with new ideas to deal with bacterial infections: drugs not directly kill bacteria that cause infection, but to undermine the effectiveness of toxins secreted by the bacteria, thus making the symptoms alleviated and will not kill other dead bacteria at the same time. Certain proteins produced by clostridium difficile can cause inflammation of the intestinal tract. Stanford University researchers screened a large number of compounds, and found a selenium-contained compound which is called Ebselen can act on these proteins and make them ineffective.
Experiments in mice showed that this compound can effectively alleviate the symptoms of infection caused by clostridium difficile. Although further clinical trials have not yet started, clinical trials of applying this compound to the treatment of other diseases are already underway. The researchers hope that this compound will soon be able to help those who suffered the clostridium difficile.
Related reading>> http://www.cusabio.com/Clone/RSc1635-1089576.html
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