Chinese institute promotes analysis of important protein structures

Recently, researcher Tang Chun group from Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences made use of the new research technology established and based on the 973 major scientific research program "New technological developments in protein research new approach" to assist Professor Yin Ping at Huazhong Agricultural University to firstly analyze the complex structure of N6 adenine methyltransferase METTL3-METTL14 protein, and the research findings were published in the journal Nature. The journal also provides other studies on recombinant proteins such as recombinant rat proteins.

The study reveals the structural basis of RNA N6 adenine methylation modification process and is a major breakthrough in the field of epigenetics. Tang Chun, associate researcher Gong Zhou and postdoctoral Liu Zhu at Wuhan Institute of Physics and Mathematics were involved in the project. They made use of new methods and technology developed by the research group to provide help in research approach for structural analysis of the protein complex through the method of combining of small angle X-ray scattering and computer simulation.

After nearly three years of efforts, Tang Chun group has developed and established a variety of biological, physical and chemical methods including NMR spectroscopy, small-angle X-ray scattering, chemical cross-linking mass spectrometry analysis, single molecule fluorescence detection and imaging technology. They also developed corresponding integration calculation method for the study of dynamic structure of protein and its conversion process. In addition to completing their own scientific research projects, the research group actively carries out extensive cooperation and exchanges and shared research technologies and methods with domestic and foreign counterparts. Currently, thanks to the implementation of the "New technologies and new approaches of protein dynamics studies" project, the research group has promoted the analysis of many important protein structures and made a series of research results. Their findings were published in world-class journals such as Nature - Chemical Biology and eLife. Flarebio provides you with various recombinant proteins including recombinant ECE1 of good quality at competitive price.