Vitamin D is associated with mucosal inflammation of patients with Ulcerative colitis

According to the results of a prospective study, the concentration of serum 25-hydroxy vitamin D and mucosal inflammation in patients with ulcerative colitis are negatively correlated with disease activity. The treatment of UC includes the technologies of recombinant proteins. Related content has been published online in the journal The American Journal of Clinical Nutrition.

"The incidence of Vitamin D deficiency is very high in patients with inflammatory bowel disease." Said Dr. Joel Pekow at Digestion Department of University of Chicago. Pekow and colleagues evaluated concentration of serum 25-hydroxyvitamin D of 230 UC patients [25 (OH) D] (mean age 45.8 years; the average duration, 166 years; 53% male; 90% Caucasian) and compared their inner Mayo endoscopic scores, overall Mayo score and histological activity. They also compared expression concentration of colonic mucosa epithelium connected proteins and inflammatory cytokines in patients with low serum 25 (OH) D concentrations and high serum 25 (OH) D concentrations relatively low serum 25 (OH) D concentrations and high serum 25 (OH) D concentrations to determine whether enough levels of vitamin D is related to the protection of epithelial cell junction proteins and the reduce of gastric mucosa inflammatory cytokines. The research also used various recombinant dog proteins.

"The vast majority of UC patients have deficiency or insufficiency of vitamin D, mucosal inflammation in patients with ulcerative colitis is related to the decrease of serum 25 (OH) D levels," Pekow said. The overall serum 25 (OH) D concentration was 21.8ng / ml, and serum 25 (OH) D concentration Mayo endoscopy score (P = 0.01), overall Mayo score (P = 0.001) and histological activity (P = 0.02) were negatively correlated.

In addition, the condition of serum 25 (OH) D concentration is less than 20ng / ml is related to mucous membranes reduce transcription, vitamin D receptor (VDR) and a closed-cadherin protein expression concentration. In contrast, in patients with serum 25 (OH) D concentrations below 20ng / ml, pro-inflammatory cytokines TNF-α and mucosa transcriptional expression concentration of interleukin-8 increased. "In UC patients, serum 25 (OH) levels were proportional to mucosal expression of VDR and epithelial cell connected proteins and inversely proportional to the pro-inflammatory cytokines. The results support investigation that vitamin D is effective protection of active inflammation of UC." Pekow Said. Flarebio can provide you with high-quality recombinant proteins such as recombinant APP, please stay tuned.