Scientists have found the cause of various types of congenital defects

Scientists first believe they have found the cause of various types of congenital defects caused by environmental pressure. The breakthrough achieved by scientists at Zhang Renqian research Institute indicated that cell stress may be the key to understanding why many babies show defects in heart, spine, kidney when they are born. The research Institute also conducts much other research on recombinant proteins such as recombinant dog proteins.

The study was led by world-renowned professor Sally Dunwoodie. The researchers analyzed the impact of short-term lack of oxygen during embryonic heart development. "Obviously, we all know that smoking has very bad influence on the unborn baby's health. But the embryo hypoxia can be caused by many things, such as prescription drugs, high blood pressure, high altitude, cord entanglement and carbon monoxide," explained Professor Sally Dunwoodie.

Using a mouse model, the scientists reduced from the indoor oxygen content from 21% which was the normal level to 5.5% for 8 hours. Scientists first discovered that reducing oxygen levels can damage the developing heart. The types of heart defects are the same to the most common types in humans. Importantly, scientists have worked out exactly how the oxygen content damages the developing heart.

"We found that the reduce of oxygen content would trigger embryonic cells to show stress reaction. Embryonic cells try to reduce stress by stop making proteins. In the research, the researchers used recombinant horse proteins to get more results. In the critical stage of heart development, the heart can’t properly develop with a sudden lack of proteins." Dunwoodie Professor disclosed.

Importantly, hypoxia in environment is not the only trigger of cell stress. There are many factors that can lead to hypoxia of embryo, such as viral infections, temperature, high blood sugar, malnutrition and pollution. "This cellular stress reaction may be the key that causes a variety of birth defects not just heart defects. Now, we strongly suspect that this is the mechanism of many different types of birth defects, including vertebrae, kidney and other defects."

"Surprisingly, this cell stress reaction has been used by our body for hundreds of millions of years. But until now, we find out that it could lead to abnormal development of organs like heart." Professor Dunwoodie added. At present, the research results have been received by the journal Development. Flarebio provides you with high-quality recombinant proteins including recombinant CDH2 at a good price.