Get to know the mechanism of air pollution inducing lung cancer

Through in-depth study, Zhou Guangbiao research group from Animal Institute of Chinese Academy of Sciences found the key long-chain non-coding RNA of air pollution-induced lung cancer. Related achievements were published recently in Oncology journal Oncotarge. According to study, some recombinant proteins can inhibit lung cancer.

It is understood that lung cancer has become the cancer with world's highest incidence and most deaths, and 90% of lung cancer is caused by smoking, air pollution and other environmental factors. However, the mechanism of air pollution-induced lung cancer molecular is unclear.

Previous studies have shown that air pollution can make organism genomes show a large number of mutation; inflammatory cytokines CXCL13, CXCL20, miRNA-144 and other factors play an important role in lung cancer air induced by pollution and smoking. In this study, the researchers analyzed the role of long-chain non-coding RNA (lncRNA) in lung cancer caused by air pollution.

It is understood that IncRNA is a class of non-coding RNA which can regulate gene expression in transcription, post-transcriptional and epigenetic levels. By lncRNA chip, the researchers found that lung cancer samples in air pollution area contained more lncRNA with abnormal expression, and CAR10 is a long non-coding RNA associated with air pollution. Studies have shown that high expression of CAR10 is associated with air pollution.

Further studies showed that dibenzanthracene in PAHs family promoted CAR10's expression in lung epithelial cells through transcription factor FoxF2, while after binding to transcription factor YB-1, CAR10 inhibits its degradation by the proteasome and causes accumulation of nucleus YB- 1 protein and promotes expression of epidermal growth factor, thereby promoting cell proliferation and inducing lung cancer. Flarebio provides you with high-quality recombinant proteins such as recombinant CDH11 at competitive prices.