iRhom2 plays an important role in innate immunity to DNA viruses

Natural immunity is the first line of defense for the body to fight viral infections and plays a key role early-stage antiviral immunity for a host. On July 18th, immunology authoritative journal Nature Immunology published the latest research results in the field of anti-DNA virus of innate immunity by Shu Hongbing Research Group at Wuhan University and the study is titled "iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING". They also developed recombinant proteins such as recombinant horse proteins and recombinant dog proteins for the research.

The study firstly reported the important role of rhomboid-like protease in the anti-DNA viral innate immune response, providing new clues for understanding the physiological function of these kinds of proteins. More importantly, the study describes the important regulatory mechanism of body's anti-viral immune response of DNA, providing a potential molecular target for the prevention and treatment of related diseases caused by DNA virus infections and autoimmune diseases.

In the latest study, the Shu Hongbing Research Group found iRhom2 proteases play an important role in the anti-DNA virus natural immunity. They used gene-knockout mouse models to confirm that iRhom2 is essential for the host against DNA viral infections. Experiments of biochemistry and cell biology showed that iRhom2 regulated STING through two relatively-independent pathways. On the one hand, iRhom2 transported related protein TRAPb to STING through bridging to promote STING to be transported from the endoplasmic reticulum to microbody in nuclear periphery region and activate downstream transcription factor IRF3 in the process; on the other hand, iRhom2 recruited deubiquitination enzyme EIF3S5 and maintained stability of STING at protein level by removing K48 connection ubiquitination of STING, thereby promoting the activation of downstream transcription factors IRF3. There are many IRF3 recombinant human proteins on sale in the market.

Back in 2008, research group led by Shu Hongbing Research Group and Glen Barber from University of Miami independently discovered a connector protein STING/MITA which plays a key role in anti-DNA virus innate immune. The discovery aroused widespread attention and soon became a hot topic in the field of immunology, and relevant literature papers had become important documents in the field of immunology.

The research work of this paper was mainly completed by doctoral student Luo Weiwei guided by academician Shu Hongbing and young teacher Dr. Li Shu and other fellows, and Shu Hongbing is the responsible author of the paper. The study was funded by Major National Scientific Research Projects and the National Natural Science Foundation of China. Flarebio provides superior recombinant proteins such as recombinant Pigr at a good price. Please feel free to inquire more.