The relevance between vitamin D levels and outcomes

In May of 2016, a study published in the journal J Clin Oncol investigated the relevance of vitamin D levels in melanoma patients and the outcomes after correcting C- reactive proteins. The results showed that low vitamin D levels of melanoma patients were associated with a worse outcome. Although lower vitamin D is strongly associated with higher CRP, the relevance of low vitamin D with poor OS, MSS and DFS is independent of this correlation. The result was got from the use of various recombinant human proteins.

Objective: after detecting and controlling systemic inflammatory response (SIR) according to C- reactive protein (CRP), to assess the relevance of 25-hydroxyvitamin D levels (vitamin D) in melanoma patients with and the outcome.

Materials and Methods: To test vitamin D and CRP of plasma samples of prospectively-observed 1,042 melanoma patients. To investigate correlation of demographics and CRP with vitamin, followed by was further analyzing the correlation between vitamin D and drawing blood stages and ending tests. If vitamin D levels are between 30 and 100 ng / mL, it is considered to be adequate and can conduct Kaplan-Meier and Cox regression analysis.

Results: The median level of vitamin D was 25.0 ng / mL. Median follow-up was 7.1 years. Lower vitamin D was related to drawing blood (P <0.001) in autumn / winter, older age (P = 0.0105) and advanced melanoma (P = 0.0024). In univariate analysis, lower vitamin was related to poor overall survival (OS; P <0.001), melanoma-specific survival (MSS; P = 0.0025) and disease-free survival (DFS; P = 0.0466). After adjusting for CRP and other covariates, the impact of vitamin D on the outcome of this detection still existed. With one unit reduction of Vitamin D, the multivariate hazard ratio of OS was 1.02 (95% CI, 1.01 ~ 1.04; P = 0.0051), and that of MSS was 1.02 (95% CI, 1.00 ~ 1.04; P = 0.048); that of DFS is 1.02 (95% CI, 1.00 ~ 1.04; P = 0.0427).

Conclusion: low vitamin D levels of melanoma patients are associated with a worse outcome. Although the lower vitamin D is strongly associated with higher CRP, the relevance between lower vitamin D and poor OS, MSS and DFS is independent of the correlation. The survey of explanations on these related mechanisms is of great importance for melanoma patients. Flarebio provides you with superior recombinant proteins including recombinant Insr.