Same DNA fragments can match with each other without the help of other molecules

A new study results show that without the help of other molecules, same DNA fragments can match with each other. Genes (genetic factors) are DNA fragments with genetic effect. The results showed that each encoding gene has specific properties, no matter biological properties or biological functions. However, a gene can't always keep intact. It would often show damages and need diagnosis and repair.

The repair process of encoding genes is called homologous recombination. In this process, a broken or damaged gene can be replaced as the complete DNA sequence of the same gene. Wrong interchange of genes would lead to a variety of genetic diseases such as condition progeria, an accelerated symptom of aging.

Gene repair and homologous recombination is the key to reproduction and evolution, because this restructuring process would recombine the genes we obtain from our parents together. Recombinant protein are involved in replication and gene substitution process. However, in the genetic recombination process, the protein will react spontaneously. But the researchers didn't know how homologous genes found each other at that time. In the human genome, after coiling, DNA strand forms complex gene beam, i.e. chromosome. On the chromosome, there are more than 20,000 genes. Therefore, for different DNA strands, it is not easy to find homologous genes.

Imperial College London and the US National Institutes of Health (NIH) carried out a DNA molecule experiment in 2008, and the results showed that without any outside help (i.e. without any guidance of other proteins and molecules), DNA molecules which have the same genetic code can find their pair fragment.

These results show that two relatively- short double-stranded DNA fragments would spontaneously match with the same types of DNA after being mixed randomly in a container. Professor Mara Prentiss from Harvard University also confirmed in the subsequent study that homologous double-stranded DNA can spontaneously match. Flarebio provides you with high-quality recombinant proteins including recombinant CDH4 at a competitive price.