It is not suggested to use Vitamin D to relieve pains and cartilage loss caused by knee osteoarthritis

A recent study reveals that supplement of vitamin D for the patients who suffer from knee osteoarthritis and 25-hydroxy vitamin D levels does not reduce knee pain or relieve cartilage loss.

In males and females who aged 60 years or older, the percentage of osteoarthritis symptoms were 10% and 13%. There is no treatment to alleviate bone arthritic disease at present. Vitamin D can reduce cartilage degradation and bone turnover, thus it may prevent the development and progression of knee osteoarthritis. Observational studies suggest that vitamin D is related to benefits brought by osteoarthritis, but the evidence from clinical trials is conflicting.

Changhai Ding, Australia University of Tasmania, Hobart, Tasmania, MD, Ph.D., And colleagues randomized 413 patients suffering from symptomatic knee osteoarthritis and 25-hydroxy vitamin D concentrations assigned to receive low monthly oral vitamin D3 (50,000 international units; n = 209) or identical placebo for the treatment of up to 2 years. The study was conducted in Tasmania and Melbourne in Australia.

In the recruitment of 413 research participants (average age is 63 years old; 50% are females), and 340 (82%) completed the study. The researchers found that in the course of two years, comparing with placebo, vitamin D supplementation did not cause any significant difference between MRI detected tibial cartilage volume and knee pain detection. Two groups of patients tibial - femoral or tibial cartilage defects - femur bone marrow lesions also showed no significant difference. In the course of two years, the concentration of vitamin D in patients with vitamin D group had no more improvement than the placebo group.

The authors wrote, "These data suggest that, to slow down the progression of vitamin D or structural changes of knee osteoarthritis disease lack for supporting evidence."

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Too low or too high levels of Vitamin D both could be bad for health

According to the study of Danish scientists, high or low levels of vitamin D are detrimental to health. We may need to reconsider the nutrient intake.

Human blood vitamin D levels should not be too high or too low. According to scientists at the University of Copenhagen study, the first time they show there is a correlation between high levels of vitamin D content of death and cardiovascular disease. From a public health point of view, a lack of vitamin D has been a focus of attention. Several studies have shown that blood vitamin D levels are too low and a higher risk of dying from coronary heart disease or stroke-related. The study was published in the "Endocrinology and Metabolism."

"We studied 247,574 Danes‘blood levels of vitamin D, which is the maximum amount of data of such research. After extracting the initial blood samples of the testees, we analyzed the death rate in the last 70 years, during which there were 16645 deaths of patients. In addition, we also investigated the relevance between their death and the vitamin D levels in their blood, “explained Professor Peter Schwartz at Institute of Clinical Medicine Schwarz. The conclusion is obvious. Study confirmed relevance between the death rate and low levels of vitamin D, but the new finding also shows that higher vitamin D levels are also risk factors.

"If your vitamin D levels of blood are below 50 nanomoles or higher than 100 nanomolar per liter, then it is more relevant to death. We investigated the cause of the patients' death and found that, when the blood vitamin D levels are higher than 100 nanomolar, the higher risk of dying of stroke or coronary heart disease for the patient. In other words, the content of vitamin D in the blood should not be too high or too low. It should be between 50 to 100 nmol per liter. Our studies have shown that 70 nanomolar should be the most appropriate level, “Schwartz states.

No previous studies have shown high levels of blood vitamin D are also harmful to health. It may affect our future intake of nutrients supplements before that.

"This conclusion is very important because modern people are more and more concerned about the supplement of vitamin D. Taking this opportunity, we should consider more about whether it is suitable to intake more vitamins and other nutrients. And we also need to consult with a doctor on such a problem." Schwartz Says.

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