A recent study reveals that supplement of vitamin D for the patients who suffer from knee osteoarthritis and 25-hydroxy vitamin D levels does not reduce knee pain or relieve cartilage loss.
In males and females who aged 60 years or older, the percentage of osteoarthritis symptoms were 10% and 13%. There is no treatment to alleviate bone arthritic disease at present. Vitamin D can reduce cartilage degradation and bone turnover, thus it may prevent the development and progression of knee osteoarthritis. Observational studies suggest that vitamin D is related to benefits brought by osteoarthritis, but the evidence from clinical trials is conflicting.
Changhai Ding, Australia University of Tasmania, Hobart, Tasmania, MD, Ph.D., And colleagues randomized 413 patients suffering from symptomatic knee osteoarthritis and 25-hydroxy vitamin D concentrations assigned to receive low monthly oral vitamin D3 (50,000 international units; n = 209) or identical placebo for the treatment of up to 2 years. The study was conducted in Tasmania and Melbourne in Australia.
In the recruitment of 413 research participants (average age is 63 years old; 50% are females), and 340 (82%) completed the study. The researchers found that in the course of two years, comparing with placebo, vitamin D supplementation did not cause any significant difference between MRI detected tibial cartilage volume and knee pain detection. Two groups of patients tibial - femoral or tibial cartilage defects - femur bone marrow lesions also showed no significant difference. In the course of two years, the concentration of vitamin D in patients with vitamin D group had no more improvement than the placebo group.
The authors wrote, "These data suggest that, to slow down the progression of vitamin D or structural changes of knee osteoarthritis disease lack for supporting evidence."
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