PNAS: the secret of aging is can be revealed by your body metabolin

Metabolites produced during metabolism can provide a lot of information on individual health, disease, diet and lifestyle. Now, they can tell us more. Researchers and collaborators at Japan Okinawa University Institute of Science and Technology (OIST) Kyoto University recently found some particular metabolites associated with aging, and illustrates the process of body aging. Professor Yanagida at OIST led the team and published their results in the journal PNAS.

To find and analyze these metabolites, the researchers obtained blood samples containing red blood cells (RBCs) including 30 healthy individuals: including 15 young adults (29 ± 4 years) and 15 elderly (81 ± 7 year old). In the past, all the studies had ignored RBCs, but because RBCs accounts for nearly half of the volume, the researchers believe it is worth exploring.

Then they used a technology called liquid chromatography - mass spectrometry (LC-MS), identifying metabolites in the blood. Thus, they can calculate the coefficient of variation or standard deviation by dividing average abundance of metabolites to determine the compound which is increased or decreased in vivo in the elderly.

Yanagida said, "We found 14 kinds of age-related compounds. Of these 14 compounds, half of them decrease in the elderly. The study found the reduced compounds are those which are antioxidative or muscular strength related. Thus, the elderly have fewer antioxidants and weak muscle strength.

The other half of the compound is increased and decreased liver and renal function related metabolites. Yanagida said, "This makes sense. Common sense tells us that, as we age, we lose muscle and kidney function ability, but in the past with no scientific way to confirm this is the case." In addition, some occur in the same age-related metabolic signaling pathway metabolites associated changes occurred, indicating the age affect them."

Yanagida said, "Some of the functions related to the compounds show the same tendency to increase or decrease with age, or in other words, they show a similar correlation."

Because of these identified age-related metabolites, antioxidants and muscle strength decrease that consumption of foods high oxides and exercise is very important, especially after 65 years. This can help raise the level of the relevant metabolites in vivo, improve the physical condition. Although still left a lot of longevity and healthy living related unknown composition, the research team will continue to reveal more information about healthy aging.

Yanagida said, "Longevity is a huge puzzle for us. We want to learn how you can make the elderly happy to spend the last leg of life's journey. This is a way we can contribute to human health."

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