Breast cancer is one of the most common cancers in women, but also one of the most serious cancers. Between 40-60 years of age, the incidence of post-menopausal women is high and only about 1-2% of breast patients were male. This cancer usually occurs in mammary epithelial tissue, it will seriously affect women's health and even life-threatening. TNBC breast cancer is one of the most dangerous, accounting for 16% of breast cancer.
Fudan University Cancer Hospital research team TNBC conducted transcriptome analysis reveals a comprehensive mRNA-lncRNA prognostic indicators. The study was published in the February 29 Journal of Cancer Research, one of the top ten oncology journals, articles Corresponding author is Professor Shao Zhimin Fudan University Cancer Hospital.
Professor Shao Zhimin research team hopes to develop RNA in patients with TNBC indicators in order to better assess the risk of cancer, choose a more suitable adjuvant therapy. They transcription chip TNBC group and normal breast tissues were analyzed to identify the recurrence of breast cancer tumor-specific mRNA and a long non-coding (lncRNA).
On this basis, the researchers developed an mRNA-lncRNA comprehensive index, mRNA including FCGR1A, RSAD2 and CHRDL1, lncRNA including HIF1A-AS2 and AK124454. They then evaluated using this indicator to judge the accuracy of prognosis. Studies have shown that this RNA is more reliable indicator than clinicopathological parameters. This study has provided people with a reliable tool to predict recurrence TNBC, it laid the foundation for further large-scale studies can help doctors provide personalized therapy for patients with TNBC.
Breast cancer is easily spread to the bones, lungs, liver, lymph nodes and brain. The effect of anti-cancer drugs for the treatment of early cancer of the best, so early detection is critical. Detection of breast cancer imaging techniques (including MRI) not reflect the type of cancer cannot be detected early growth of cancer cells currently used. Case Western Reserve University researchers have developed a magnetic resonance imaging (MRI) technology; can detect early biological markers of breast cancer recurrence.
The immune system is the body's fight against disease, infections and even cancer of the armed forces, but the team will also appear traitor. Netherlands Cancer Institute scientists published an article that breast cancer can be "instigation" of specific immune cells, promote the spread of cancer in the journal Nature.
Our body always has some developmental potential of adult stem cells, which are responsible for repairing damaged, replace aging of cells and tissues. Cancer also has some similar with adult stem cells, capable of self-renewal and differentiation by start and sustain the formation and development of cancer. People speculate, may share some of the molecular mechanisms between normal and malignant stem cells. Professor Kang Yibin research team by breast cancer study provides direct evidence to support this view.
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