Crohn's disease patients and ulcerative colitis patients show difference of the microbiota

Recently, a study published in the journal Inflamm Bowel Dis reporting that no significant difference in microbiota composition of inflammatory and non-inflammatory mucosa between patients with Crohn's disease (CD) and patients with ulcerative colitis (UC). However, the researchers found the differences between the two diseases in inflammatory and non-inflammatory mucosa.

"This study shows the difference in microbiota bacterium spectrum of CD, UC or inflammatory bowel mucosa," said Dr. Charles N. Bernstein at Inflammatory bowel disease Clinical and research center in Manitoba University.

Bernstein and colleagues compared bacterial communities of IBD patients in inflammatory and non-inflammatory gastrointestinal mucosa. They were collected from 15 patients with CD, 21 UC patients and 7 patients with non-inflammatory bowel biopsies in 166 parts by colonoscopy. Each patient collected 3-4 parts of ileum, cecum, the colon or rectal biopsy. When the internal CD patients with non-inflammatory and inflammatory bowel mucosa were compared, no significant differences were found in any genus door. We have the same results in patients with UC tissues.

However, when patients with CD and UC patients with inflammatory non-inflammatory mucosa were compared, the differences appeared. Compared with inflammatory UC mucosa, the mucosal inflammatory CD Bacteroides door (P = 0.002) and Clostridium (P <0.05) were detected on the door often grade level; Proteobacteria and Firmicutes (P <0.05) regular checks on the inflammatory mucosa of patients with UC.

Between a group of inflammatory CD and UC groups, soft clostridium group (P≤0.05), Bacteroides (P = 0.003), and Pseudomonas (P <0.001) in the number of significantly different genus level. In the CD group and UC group, 13 species abundance significantly different. No inflammatory bowel disease compared to the control group, non-inflammatory mucosa of patients with UC is the most different.

"Our study shows a comprehensive analysis of intestinal microflora, researching on different segments of the intestinal mucosa inflammatory or non-inflammatory," the researchers concluded. "While we have come to this conclusion that mucosal microflora composition doesn't change according to different inflammation, we can find an interesting phenomenon that microbiota of non-inflammatory intestinal microflora of IBD patients shows more diversification than that of inflammatory bowel microflora."

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