New antitumor immune pathway can help mammals fight against the virus' carcinogenic function

Researchers Southwestern Medical Center University of Texas identified a new pathway of innate immunity which can help mammals resist against carcinogenic virus. The study was recently published in the journal PNAS.

Virus-related cancer is actually quite common, "over 20% of human cancers and chronic viral infections," first author Dr. Xiaonan Dong said. Dr. Dong graduated from Tsinghua University seeks to reveal the host - pathogen interaction of molecular mechanisms, in particular autophagy in innate immunity role.

Autophagy is a fairly conservative process, cell by autophagy to clear damaged proteins and organelles. Studies have shown that autophagy-related protein beclin 2 can promote the decomposition of oncogenic viral proteins, inhibit cancer and viral infections caused.

Improve beclin 2 expression, Kaposi sarcoma-associated herpes virus G protein-coupled receptor (GPCR) degrade rapidly, reducing signal transduction promote tumorigenesis. Reduce beclin 2 expression, GPCR virus persists, promote tumorigenesis. This response is part of the endosomal lysosomal transport, and bacterial protein is fed to the lysosome through this process.

"We have a better understanding of the immune system against cancer-causing virus mechanism," who led the study, Professor Dr. Beth Levine said. "Help identify new therapeutic targets and develop new anti-viral therapy."

EB virus (EBV) is a ubiquitous herpesvirus type 4, is closely associated with many tumors, including Burkitt's lymphoma, Hodgkin's lymphoma, stomach cancer, nasopharyngeal carcinoma, and so on. According to statistics, more than 90% of the adult body have lurked virus. EBV infected B cells process has been studied extensively, but it is the mechanism of EBV infection of epithelial cells is still poorly understood. Sun Yat-sen Cancer Center and Harvard Medical School research team found that, NMHC-IIA nasopharyngeal epithelial cells is an important factor-mediated EBV infection.

HPV is one of the most common sexually transmitted viruses and HPV-induced head and neck cancer is increasing year by year. People need to understand molecular changes HPV-positive head and neck cancer, and the development of new therapeutic strategies based on this. Nature magazine published by far the most comprehensive head and neck cancer genome sequencing analysis. Cancer Genome Atlas Program (Cancer Genome Atlas, TCGA) scientists revealed the human papillomavirus (HPV) and the impact of smoking on the head and neck cancer, head and neck cancer compared with other cancers of the similarities and differences, for the diagnosis and treatment of head and neck cancer provided new direction.

Cervical cancer is the second leading cause of cancer in women, especially common in developing countries, where early screening is not common. It found that almost all cervical cancer is the human papillomavirus (HPV) infection. Scientists have long thought that estrogen is the main factor driving the growth of cancer. However, a study published in the journal PNAS shows that the estrogen receptors in cancer cells almost all disappear.

More can be found here: http://www.cusabio.com/ELISA-Kit/Bovine-C-telopeptide-of-type-%E2%85%A1-collagenCTX-%E2%85%A1-ELISA-Kit-1035497.html