Microbial distribution location decision lifespan

We already know that the composition of intestinal microflora changes will affect our health. For example, there are some specific microorganisms may lead to the occurrence of certain human cancers; or alter the normal metabolism of people; some microbes may even accelerate human aging.

Metazoan gastrointestinal health is very important to the district. Each region of intestine and stomach has various gastrointestinal specific microorganisms. If ecological imbalance of these microorganisms happens, it can cause gastrointestinal disorders.

And the link between the phenomenon that gastrointestinal followed with microbial imbalance and gastrointestinal partitions is still unclear. Recently in Drosophila, scientists found that the change of venue of their gastrointestinal microbial composition and distribution will shorten its life.

In a recent article published in Cell Host & Microbe, scientists found that after further study, the microbial distribution and formation of young flies have relevance with distribution of intestines and stomach. While in the Drosophila stomach of elderly flies, since the inflammatory signals lead to cell aging stomach wall and status is changed, the emergence of metaplasia stomach, gastrointestinal partition declined. The presence of a particular region also will be distributed prior to microbial disorder. JAK / activation associated with aging Stat signaling pathway leading to the inner wall of the stomach tissue deformation. If the stomach tissue and suppresses JAK / Stat signal can prevent microbial imbalance, thereby extending the life of fruit flies. This suggests that microbes on human health, their specific location in the stomach tissue is critical!

Their findings explain the physiological mechanism that chronic inflammations associated with age cause the decrease of gastrointestinal partition, thus resulting in the regional microflora imbalance, ultimately limiting animal life.

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