Kongqing Peng group from the kunming institute of zoology Chinese Academy of Sciences collaborated with Hainan Medical College systematically studied genetic protection factors associated with health and longevity, identifying differentially expressed genes associated with longevity. Related achievements have been published recently in the journal Science Report.
Researching and mining the health protection factors of longevity and its pedigree shows great importance for the development of aging-related disease prevention and health policy.
Kongqing Peng cooperation team took Hainan health and longevity as the study population. Through more than 100 samples of health condition and blood biochemical indicators of longevity family’s health, they found: in the aging process, the total levels of triglyceride (TG) and cholesterol (TC) gradually raised high, but they showed a downward trend among the long-lived people. Similarly, although renal function continued to decline with age, the relevant indicators (blood urea nitrogen, creatinine, etc.) had been well maintained in the elderly with longevity.
Cardiovascular disease is the leading cause of death among adults, and the deterioration of blood lipids and renal function is a risk factor for cardiovascular disease in adults. The improvement and maintaining of these indicators among longevity populations may be an important reason that fewer long-lived people suffer from cardiovascular disease. To further define the reasons for improvement in these indicators, the research group conducted transcriptome test on peripheral longevity family members. They successfully identified differentially expressed genes which were significantly associated with these indicators, indicating that the trait did show the base of genetic regulation.
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