Leukemia is a malignant tumor in hematopoietic system, commonly known as "blood cancer". In this disease, certain types of leukemia cells show neoplastic hyperplasia in bone marrow or other hematopoietic tissues, they can infiltrate the body's different organs and tissues, resulting in dysfunction of each organ and producing signs and symptoms. The leukemia can be divided into acute and chronic categories according to the cell differentiation.
In recent years, people gradually realized that the extracellular microenvironment vesicles (MV) play an important role in the development and recurrence of cancer. Researchers at Chinese Huazhong University of Science and Technology published an article in the journal Cancer Research that the miRNA in micro vesicles will push leukemic transformation of hematopoietic cells. The corresponding author of the article is Professor Guoan Yuan at School of Life Science and Technology of Huazhong University of Science and Technology.
Studies have shown that chronic myeloid leukemia (CML) K562 cell micro-vesicles, to make into leukemia-like cells in normal hematopoietic stem cells. The researchers found that in the early stages of the micro-vesicles hematopoietic stem cell malignant transformation initiated a number of anti-cancer miRNA pathway and defense, but later involved in cell cycle, DNA repair and energy metabolism and carcinogenicity of miRNA genes up-regulated.
Further studies have shown that high levels of expression in micro vesicles miR-146b-5p regulate cancer-related genes, and thereby promote the transformation of hematopoietic cells. This miRNA inhibitor NUMB main function will increase the level of ROS cells, enhancing genomic instability by silencing tumor.
Genes are the blueprint for a protein, while miRNA helps cells decide whether to manufacture these proteins according to the blueprint. miRNA is long non-coding RNA which is 22nt, bearing a crucial function in the regulation of important processes of embryonic development, cell differentiation and organ generation and the like. These short RNAs largely exist in natural cells. They can be paired with the target gene mRNA and hinder its translation and regulate its expression of target genes in the post-transcriptional level.
没有评论:
发表评论