Gene therapy can improve the cardiac function of patients with heart failure

A new study shows that gene therapy appears to improve the patient's heart function, which is undoubtedly an excellent news for millions of patients with heart failure.

"The end result of gene therapy is: reconstruction of damaged heart tissue, which can help patients restore mechanical function of the heart," Dr. Justine Lachmann explained. She worked at the Ministry of congestive heart failure NewYotMineola Winthrop University Hospital. For heart failure patients, their heart function weakened or impaired pumping function of the heart disorder. The American Heart Association says this deadly disease for more than 570 million Americans had an impact.

Although the disease on many people's lives had an impact, but there has not been effective in the treatment program, Lachmann represented. "We are through drug intervention, has successfully extended the life of heart failure patients, the drug can change the body produces chemical signals on the heart," she said. "But the result is still very serious long-term use, because it can cause permanent damage to the structure of the heart, such as heart attack."

In this study, the researchers recruited a total of 56 patients with heart failure, their heart function declined by 40% in this study, the researchers through the tip of gene therapy to reverse their heart damage. Gene therapy involves "gene transfer" process, i.e. a harmless virus gene to transport fine cells inside the heart. The gene, once in place, it will produce a protein called AC6, the researchers said that this protein can improve the situation of failure of heart cells.

Some patients had been treated in the new study, while others took placebo. Researchers conducted a one-year follow-up investigation for the participants.

The related articles of the research are published online on March 30th in the journal JAMA Cardiology. Studies show that AC6 gene transfer therapy appears to help restore heart function. Researchers found that gene therapy will increase drug treatment effect.

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