Efficient photothermal tumor treatment based by heat shock protein developed by Chinese scientists

Professor Zhou Jingfu at Capital Normal University made use of new-type soft template synthesis method to synthesize rare-earth conversion luminescent nanomaterials with a porous structure, and they took it as a vector between small molecule photothermal conversion material cypate and heat shock protein siRNA. By interfering with the synthesis of heat shock protein, they achieved an efficient photothermal tumor therapy of multi-mode imaging guidance, providing a new idea for increasing the depth of treatment, improving the therapeutic effect and reducing the side effects of treatment.

Heat shock proteins are a class of heat-related proteins which exist widely in all living organisms, from bacteria to humans. Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. When the organisms are exposed to high temperature, they will synthesize such protein to protect themselves. Thus, inhibiting synthesis of heat shock protein can reduce the heat resistance of tumor cells so as to enhance the effectiveness of photothermal tumor treatment and reduce the temperature of treatment required. In addition, by visualization means of multimode imaging can they effectively locate the tumor, further enhancing the photothermal efficacy and safety.

The findings were published in the journal Adv. Funct. Mater. More information about protein can be found in Cusabio which is a company specialized in the production and sales of recombinant proteins and antibodies. Feel free to contact Cusabio.

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