Fluorescent dyes biometrics in the biomedical field has a very broad application prospects, particularly special fluorescence identifying and fluorescence imaging have the characteristics of being fast, safe, efficient and non-invasive, are ideal for the early diagnosis and guide treatment of diseases in organizations or in vivo.
Recently, Zhu Weihong research group at College of Chemistry, East China University of Science and Technology achieved recognition in the near-infrared fluorescent dye research important progress, the successful implementation of β- galactosidase real-time in vivo and in situ detection, and access to the high-resolution three-dimensional in vivo imaging signal, the tumor tissue of precise positioning. Relevant research results are published as "Real-Time Tracking and in Vivo Visualization ofβ-Galactosidase Activity in Colorectal tumor with a Ratiometric Near-Infrared Fluorescent Probe" online in American chemical Society. The work is mainly done by doctoral Gukai Zhi Guo and former Associate Professor, and has been ably assisted Biological Engineering Professor Shi Ping.
β- galactosidase is an important marker of cell aging process and primary ovarian cancer and other related diseases and benzopyran nitrile group is a near-infrared fluorescent dye signal group. The group skillfully constructed of β- galactosidase specific recognition rate of near-infrared fluorescence probes detection performance β- galactosidase when ratio and enhanced near infrared signal in response to the two modes, successfully achieving quantitative detection in living cells by endogenous β - galactosidase. They used near-infrared specificity and high-sensitivity fluorescence signal to achieve precise positioning of tumor tissues with β- galactosidase overexpression.
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