International School for Advanced Studies developed a gene therapy that can effectively help treat one aggressive brain tumors: glioblastomas. The key factor in the treatment of the disease is Emx2 gene. The genetic research now has been published on Oncotarget which can be found at SISSA website.
Emx2 is responsible for suppressing the growth of one type of glial cells - astrocytes during embryonic development. Astrocytes with large prominent part, it's shaped like stars. It, like other glial cells, and can provide protection for nerve nutrition, you can also modulate their function. During embryonic development, neurons active division was part of glial cells. After the nervous system begins to form, it will begin to reproduce astrocytes.
During this period a sharp decline Emx2 activity. This gene can regulate the growth of glial cells, according to scientists confirmed that it can be used with glioblastoma confront. This tumor and astrocyte - astrocytes set very similar. For cell culture experiments show for the first time: Activate Emx2 gene can successfully inhibit the growth of cancer cells.
Study shows: genes can contribute to the destruction of six different points of tumor metabolism. Typically there will be a lot of detours in the treatment of cancer, but the role of Emx2 gene on malignant glioma is very significant.
In the next phase of the study, the scientists conducted experiments in mice. Scientists successfully found some DNA; it will activate the malignant cells Emx2 gene. The researchers used a dead virus genes activated successfully delivered to the tumor being, they can be integrated where astrocytes genome. The results show: gene therapy successfully resisted the four variants of malignant glioma, and there is no damage to the nervous system among healthy cells.
The researchers believe that this approach can successfully prevent the recurrence of tumor.
Read more: http://www.cusabio.com/ELISA-Kit/Human-Interleukin-18IL-18-ELISA-KIT-11090105.html
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