Sirt6 genes is of great significance in delaying the aging of stem cells

According to reports, Professor Ju Zhenyu research group at Hangzhou Normal University found the important role that longevity gene Sirt6 plays in the process of hematopoietic stem cell homeostasis is of great significance for delaying aging of cells and preventing bone marrow failure syndromes, and it can be the target of the treatment of bone marrow failure syndromes. At present, four subtypes of deacetylase have been known in mammals and play a role through the interaction of the same or different enzymes and enzyme substrate. They are widely involved in physiological homeostasis such as stress regulation, fatty acid oxidation and energy metabolism, and they drop off with age. Therefore, they are closely associated with aging and age-related diseases. It has been found that promoting sirtuin (SIRT) genes to produce proteins that can extend the life of lower organisms, but its specific mechanism of stem cell homeostasis remains unclear. Ju Zhenyu said that the new study found that sirtuin enzymes (Sirtuin), the fourth class member SIRT6 protein family miss, cause the wingless gene (Wnt) signaling pathway regulated activity that overexpression of downstream genes, resulting in hematopoietic Stem cell depletion, and the use of Wnt signaling pathway inhibitors can reverse the proliferation and excessive depletion SIRT6 knockout of hematopoietic stem cells. At the same time, the study reveals an important pathway for the first time that SIRT6 gene can regulate stem cells and ageing from the level of epigenetics, providing potential target and through for the study and intervention of aging and stem cell related diseases and new perspective for exploring the biological function of longevity gene Sirt6 in regulating stem cells. Ju Zhenyu research group also found an important molecule (Wip1) in recent study. It regulates stem cell aging and tissue and organ regeneration by two aging-related signaling pathways. This important molecule phosphatase-mediated DNA damage response negative feedback regulation mechanism plays an important role in stem cell aging and tissue and organ regeneration. Read more: http://www.cusabio.com/Recombinant-Protein/Recombinant-mouse-Oxysterol-binding-protein-related-protein-11-11089629.html