High-level p62 protein may be able to detect HCC recurrence

Santiago Sangfudebo Burnham Institute for Medical Research and the University Of California School Of Medicine found that the increase of levels of p62 protein human liver is closely related to cancer recurrence, reducing the survival rate of patients. Mouse model shows that p62 protein is a necessary requirement for the formation of liver cancer. The study was published May 19 in the journal Cancer Cell, suggesting that p62 protein can be used as a prognostic marker and potential therapeutic targets of liver cancer.

Dr. Michael Karin honorary professor of pharmacology and pathology noted that promote the progression of liver cells precancerous condition factors for cancer by definition, we find a factor (p62), can be used to predict the previously completely resected liver cancer patient outcomes.

p62 protein commonly used as cellular garbage collector. p62 protein also acts as a communication hub - that combines a number of different proteins to regulate cell growth and survival and other important cellular functions. Many cancers can be found in a large number of p62 proteins, including liver cancer and liver cancer early liver disease.

The study, Karin's team had received from the treatment of liver cancer in individuals included in non-cancerous liver samples. The researchers based on the detected p62 protein mean the liver Rating: 0-3. Study included 121 cases of subjects, of which 79 cases were positive for p62 protein. Liver samples using the corresponding medical records, the research team also recorded each subject's cancer free survival years.

The researchers found that, compared to low protein levels of p62 or p62 protein is no individual, high-level individuals more prone to cancer recurrence. Further studies using 450 cases of liver cancer patients from a national research database available genomic data and clinical data recorded, the researchers found the same correlation between p62 gene and survival outcome.

Studies on mouse models of cancer before such research will affect p62 protein are attributed to other proteins (NRF2, mTORC1 and c-Myc) and its gene activation. The researchers found, p62 protein is sufficient to cause liver cancer in mice. No p62 protein, it cannot form a liver tumor.

According to Liver Cancer Institute analysis of the type of hepatocellular carcinoma, liver cancer is most common in adult. Before physicians to make treatment decisions using p62 protein information, in addition to the need for further testing, but also an urgent need for a new liver cancer detection and prevention. HCC usually do not show symptoms until late in was discovered. According to the American Cancer Society, it said all liver and bile duct cancer patients, only 17% of patients can survive for five years without cancer.

Moscat concluded, "Our new study indicates that p62 protein is a necessary requirement for inducing mouse liver tumors. When tumor is resected, liver p62 protein expression levels may predict tumor recurrence. We believe that small molecules which interfere p62 protein may contribute to the prevention of chronic liver disease to develop liver cancer."

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