Researchers at Hokkaido University and other institutions in Japan reported on 10th in the UK Journal online edition of Nature Communications that naked zokors are renowned for their longevity, and researchers used ordinary cells of the animal to successfully induce pluripotent stem cells (also called iPS cells) for the first time. Such cells are less likely to cause cancer and they can help to resolve security issues of regenerative medicine.
In Eastern Africa perched naked zokors can live 30 years. The life expectancy is about 10 times more than the normal mice, and they are not susceptible to cancer. Longevity mystery of naked zokors causes attention of many researchers in the worldwide.
Japanese researchers said in a communique that iPS cells of general mammalian have the ability to differentiate into many cell types, but there are also some risks. For example, when using cardiomyocytes differentiated from iPS cells of rat for transplantation, if these cardiac cells are mixed with undifferentiated "original" iPS cells, it could lead to cancer.
However, iPS cells of naked zokors did not show such risks. Researchers at Hokkaido University and Keio University's recently used skin cells of naked zokors firstly successfully developed iPS cells and transplanted them into naked zokor body under the undifferentiated condition of the iPS cells; concretization did not happen.
The researchers further found that the trait of stem cells of naked zokors was associated with the expression condition of their two genes, while the activities of these two genes are associated with cancer. In ordinary experimental mice, the researchers also verified the expression of one of the two genes can inhibit cancer.
The researchers said that these findings will not only help to find ways to extend lifespan but also can help to solve the risk of iPS cells inducing cancer in the field of regenerative medicine.
See more: http://www.cusabio.com/Polyclonal-Antibody/SRPRB-Antibody-11098200.html
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