Estrogen may reduce the risk of older women's diabetes ischemic stroke

A new study was designed to investigate the possible link between risk of ischemic stroke and female patients who are over 55 years old with diabetes conjugated estrogen (CEE).

This study collected information from Taiwan National Health Insurance system between 2003-2009, using CEE 55 years old diabetic female patients (0.625 mg per day) 428 cases. For comparison, 21,026 women from the same cohort of women not using estrogen diabetic patients as a control group, excluding patients with a history of ischemic stroke. Applications propensity score method according to 1: 3 ratio is determined as the control group (n = 1284). Propensity score matching covariates, including age and co-incidence. Cox proportional hazard model to estimate the relationship between CEE and ischemic stroke.

Compared with the control group, the incidence of the use of CEE ischemic stroke patients was significantly lower (0.9% VS 3%, P = 0.016 compared to). Cox proportional hazards model for further analysis showed that after adjustment for age, total incidence, socioeconomic status, urbanization and other drugs associated with ischemic stroke, patients with a lower risk of stroke CEE (HR: 0.34; 95% CI: 0.12-0.97). Because of the nature of the database, it can not determine the time of menopause.

CEE may reduce the risk of women over 55 years diabetic patients with ischemic stroke.

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