When you touch a hot stove, your fingers will immediately draw back because the tiny temperature sensor in your skin detects the heat and signals to the brain: wow! It is hot! Get away from it! According to the news website of Duke University, the school of Medicine in collaboration with researchers at the Scripps Research Institute, generate a sense of pain and heat associated with the 3D structure of the protein TRPV2 to develop receptors for pain, taking an important step to new therapy.
TRPV2 is an ion channel on the cell membrane. All the cell membrane ion channels have, as control information out of the guard cells, plays an important role in many biological processes, such as maintaining heart health, help deal with pathogens. TRPV TRPV2 is a family of proteins, which information is calcium substance, their configuration diagram deduced, contributes to the design of drugs targeting ion channels. Not long ago, researchers have drawn up TRPV family first TRPV1 protein structure showing the switch two states. In the present study, they identified the second member of the family of the 3D structure of TRPV2 by cryogenic electron microscopy and computer programs, the resolution near-atomic level.
TRPV1 exists only in the nervous system, while TRPV2 is throughout the body. The researchers compared the structure of TRPV1 and TRPV2 found TRPV2 and TRPV1 on or off the model does not match, it seems that an intermediate state. They made it a third state, this time on repetitive stimulation of ion channels become insensitive, like the condition that a man is accustomed to false alarms sound. Research on this insensitive third state is expected to indicate a new direction of relieving chronic pain.
For many conditions of chronic pain, the pain signals will continue for months or years. Currently, the number of Americans who suffers from certain acute and chronic pain is over 100 million. Diagnosis shows no causes and it is too difficult to treat. One of the researchers from Duke University said that people's perception of these receptors, the response to their environment is critical. The outcome of the working mechanism of receptor provides clues to develop new methods for treating a variety of symptoms associated with the feeling that is an essential part.
Currently, researchers are trying to induce TRPV2 to turn to other forms, thus defining its form when open or closed, and looking for structure of other TRPV family members.
More details: http://www.cusabio.com/ELISA-Kit/Human-midregional-pro-atrial-natriuretic-peptide-MR-proANP-ELISA-kit-1042031.html
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