When in resection of malignant brain tumor, doctors don't want to leave any cancer cells, but also protect the health of brain tissue, nerve damage will be minimized as much as possible. However, once a patient skull is opened, there is no time in the heavy microscope pathological analysis of tissue samples. According to the University of Washington news, the school engineer and Stanford University Memorial Sloan Kettering Cancer Center, Barrow Neurological Institute, to develop a kind of hand-held mini-microscope, so that the doctor can see during surgery cellular level to help them decide where to decisively under the knife, where the knife mercy.
New handheld microscope slightly larger than a pen point, with a new method called "dual-axis confocal microscopy technology", to more clearly "see through" opaque tissue, tissue capture half a millimeter below the surface details. One of the researchers, associate professor of mechanical engineering at Washington University Jonathan Liu said: "To see the tissue below the surface, just like the lights on driving in the fog, you cannot look too far ahead, but we use the (microscopic) like fog. Light, illuminated from different angles and reduced glares, can see farther in the fog."
To make smaller the microscope, usually at the expense of image quality or resolution, field of view, depth, contrast, processing speed and other properties. The researchers combined a fast high-quality image processing and transmission technology to achieve a balance of image indexes. They published in "Biomedical Optics Express" on paper, said miniature microscope resolution enough to see the subcellular level, organizations can image that captures the mouse and the image in the clinical pathology laboratory after several days after treatment comparable.
Jonathan Liu said the surgery to know whether the tumor has been cut in the resection. Sometimes it would be quite subjective, for the surgeon can only see with eyes and feel with tactile and brain imaging before surgery. If you can magnify tissue during surgery and see the cellular level, which helps them accurately distinguish tumor and normal tissue, it makes better surgical results.
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