Metal elements are widely used in the biosphere. Metal ions can be combined with protein in many biological fields to implement a variety of important functions. All organisms require trace metal ions, among the proteins which have been found, more than a third of them must be combined with a metal ion as a cofactor, or contain a metal binding site. Among them, the iron must be in vivo, which is the most abundant transition metal ion. Redox reaction can take place in iron. Iron has two kinds of oxidation state - divalent and trivalent, which is widely involved in various biochemical reactions.
Besides, the iron can also be combined with proteins in the form of the cofactor. Through the analysis of tendentious the distribution of protein sequences of amino acids and short peptides distribution， and through mining and analysis the pattern of information of iron-binding proteins, researchers could explore the biological and evolutionary information.
It is quite important to explore the sequence features iron-binding protein, mainly from the point of view of ferritin, research content through theory and methods of bioinformatics, combined with computer science and metals group technologies to further explore ways to ferritin binding sites and sequences.
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