Daily goods which are rich in antioxidants such as beauty skin care products, coffee, tea, red wine and vitamins may be double-edged sword under certain conditions. A research team led by Professor and director of endocrinology Zheng Hongting at Xinqiao Hospital of Third Military Medical University published a latest study confirming that antioxidants in everyday life and the clinical may promote tumor metastasis. This article entitled "pathway activation NRF2 antioxidant anti-diabetic drugs accelerated tumor metastasis" was published on April 13th in top international academic journals Science series journal - Science Translational Medicine. The researchers proposed that physicians should be more cautious when in the development of hypoglycemic treatment regimen for some patients with both diabetes and cancer.
It is understood that the correlation between diabetes and cancer had been come up at as early as in 1910 by some scholars, and a growing number of epidemiological evidence showing that diabetes is closely related with the tumor. With the rising incidence of diabetes, diabetic patients with cancer patient population are increasing. The past five years, Zheng Hongting team used mice to carry out the test, liver, colon and healthy mice antioxidant drugs were found by comparing antioxidant drugs in vivo mouse tumor lesions has shifted. After further study confirmed that some drugs can increase the antioxidant activity of the tumor cells, which will accelerate the invasion and metastasis of tumor lesions.
The findings overturn the conventional simple understanding of antioxidant and have important implications for the choice of diabetes mellitus patients with cancer hypoglycemic drug and antioxidant. They also send a warning that people should be cautious about antioxidant use in cancer patients. The journal Science - Translational Medicine said in the allotment of reviews, "Previous dietary antioxidants elements are commonly used in cancer prevention, but this study shows that antioxidant may be a double-edged sword and even has no benefit. So antioxidants should be used with caution, especially for patients with diabetes and tumorigenesis.
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