New enerated anti-cancer drugs to promote research of drug development and pharmaceutical chemistry

A team of researchers led by Professor Pauline Chiu at the University of Hong Kong chemical cortisol have generated stable protein A, a molecule capable of slowing the growth of cancerous tumors in laboratory. They published the results in the journal Chemistry-A European Journal.

Cancer is a disease with an abnormal and unregulated cell growth. Nevertheless, the tumor does not grow more than 2 millimeters unless accompanied by angiogenesis - to nourish tumors and allowed to spread to other parts of the body vascular development. Thus, inhibition of angiogenesis molecules can slow the growth of cancer.

Cortisol stable protein A is a natural product extracted from the sponge in Indonesia, there is a low-dose anti-angiogenic activity. In addition to being the main substance of anti-cancer therapy, in which cortisol stable protein a derivative is a potent anti-HIV agents. However, natural resources obtained from cortisol stable protein A is difficult, therefore, to generate laboratory is another way to get used for future research and drug development quantities.

The impressive complex structures and biological properties of the protein a stable cortisol inspired many of the world famous chemist to produce this molecule. The research team through a (4 + 3) cycloaddition reaction of cortisol generated successfully stabilized protein A, the reaction Chiu Labs research and development and optimization, to generate seven ring centered structure.

"Inventing new chemical reactions is extremely important area of research, as each new reaction is enabling tool, opened the door to generate a number of important molecules," Chiu said. "In this case, the cycloaddition reaction of our research and development is an important step in our strategy, which allows us to generate stable protein A cortisol can effectively complete."

The efficient path Chiu developed can load up the known largest stable protein A generation amount of cortisol. Its production surpasses that of half production path developed by Scripps Research Institute, and seven times the total amount generated from Harvard University. Through this way, cortisol stable protein A and its analogues can be more efficient generation to promote research and the future of drug development pharmaceutical chemistry.

Read more: http://www.cusabio.com/ELISA-Kit/Rat-Adrenocorticotropic-hormone-receptorMC2R-ELISA-kit-1081318.html