2016年4月15日星期五

Conserved gene translocation protein plays a role in regulating sleep and metabolism

The sleep time of drosophila and human is the same, and caffeine will affect their sleep. If not sleeping well at night, their memory will be affected. Recently, a study on drosophila has shown that there is a link between lack of sleep and metabolic disorders (including abnormal diabetes, obesity and blood sugar levels). The study firstly identifies conserved gene translocation protein plays a role in regulating sleep and metabolism.

Human severe insomnia and increased appetite, insulin resistance, and long-term insomnia are more likely to suffer from obesity, metabolic syndrome, type 2 diabetes and cardiovascular disease. In contrast, the metabolism of the human body clock and regulate sleep has a huge role.

The researchers said the human sleep and diet are closely related, and any of them as pathological problems and metabolic disorders. While there is considerable evidence that insomnia and associated metabolic disorders exist, but we do not know the specific connection between them it is like.

When the flies hungry, they will reduce the sleep time, sleep time as they use for food. Drosophila researchers link between sleep and feeding conducted research, you want to find out exactly what kind of genes affecting their sleep. The results found that when neurons decreased translocation of protein, fruit flies will be like hunger satiation sleep as well.

After the addition, the researchers measured sleep, glycogen, triglycerides and blood sugar levels in the fruit fly, Drosophila designed for the specific diet and the starvation response of Drosophila divided into two separate mechanisms of hunger and insomnia. The researchers said that many genes may regulate sleep and metabolism, and the study indicates the translocation of the protein plays a role in the integration of these processes. Also, insomnia caused by hunger is not due to the increase of body's nutrient storage. Thus, translocation protein is regardless of hunger or hunger-induced behavior, but it can cause insomnia when hungry.

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