Recently, Liang Bin research group at the Kunming Institute of Zoology of the Chinese Academy of Sciences found that iron overload can lead to the increase of expression of ferritin in C. elegans and fat content. The study has been published online in the journal Genetics.
Numerous clinical studies have found that the content of the body's iron and serum ferritin (dynamic iron storage protein) is highly associated with obesity-related diseases (such as diabetes and fatty liver), and reduce the iron and ferritin content can alleviate these metabolic disease symptoms. However, the molecular mechanism of fat accumulation of iron overload cause is unknown.
Model organism C. elegans life cycle is short, easy to carry out large-scale genetic screening, the researchers found, and mammals, iron overload can lead to increased expression of ferritin in C. elegans, increase the fat content.
The study found that nematode causes serum iron overload - increase glucocorticoid-induced kinase SGK-1 expression, the role of fatty acid transport protein ACS-20, a large number of lipid transport food into the cells by intracellular lipid droplet protein will lipid transported to the lipid droplets in the store, a lot of accumulation of fat leads to obesity nematodes. Meanwhile, the family of cytochrome P450 CYP-23A1 played a role in fat metabolism and balance iron metabolism, CYP-23A1 gene knockout nematodes cause more susceptible to iron overload, more fat accumulation in the cells.
The study showed that serum - glucocorticoid-induced kinase SGK-1 is a core gene of new regulation of iron metabolism and lipid metabolism. The mouse with SGK-1 knockout showed no other obvious phenotype, therefore SGK-1 is expexted to be a potential target to treat obesity and obesity-related metabolic diseases which are led by iron overload.
Go through this link: http://www.cusabio.com/Polyclonal-Antibody/CD249-Polyclonal-Antibody-11106183.html
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