Professor Ju Zhenyu research group at Hangzhou Normal University revealed the important role of longevity gene Sirt6 in maintenance of hematopoietic stem cell homeostasis. The related findings are recently published in the Cells - Stem cells.
Sirtuin is widespread in the body of a class-dependent histone deacetylase, by acting on different substrates, widely involved in stress response, steady state regulation of fatty acid oxidation, energy metabolism and other physiological processes. Sirtuin expression levels gradually decrease with age. It has been found that over-expression of Sirtuin can extend the life of lower organisms, but its specific mechanism of stem cell homeostasis remains unclear.
Ju Zhenyu group found that Sirtuin family members SIRT6 Caused by Lack of activity regulated Wnt signaling pathway, forcing the hematopoietic stem cells into the cell cycle proliferation, and ultimately led to the hematopoietic stem cell depletion; and the use of Wnt pathway inhibitor ICG001 could reverse Sirt6 knockout hematopoietic stem cells hyperproliferative and depletion.
The results in delaying stem cell aging and disease prevention and treatment of bone marrow failure has important scientific significance. At the same time, the study for the first time revealed the SIRT6 from the level of epigenetic regulation of hematopoietic stem cell development and the aging process is an important pathway, which is of great significance for in-depth understanding of SIRT6 on adult stem cell homeostasis and aging regulation and exploration of stem cell aging-related diseases intervention.
Read more: http://www.cusabio.com/Polyclonal-Antibody/BMP-2-Polyclonal-Antibody-11106185.html
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