Latest Advancement of gene sequencing technology, researchers have significantly improved the previous assembly of the gorilla genome. To better understand human biology and genetic variation, with a complete, high-quality data is quite important and we have recently relatives of non-human primate genome.
The first complete genome of a gorilla was sequenced in 2012. However, the genome contains more than 400,000 blank gene sequences, and the previous method of assembling genome has led to some inaccurate gene structure. To this end, David Gordon and others used long read sequencing technology along with a unique combination of algorithms to reconstruct an accurate much of the gorilla genome. The DNA they used was isolated from the body of a western lowland gorilla called Susie in Lincoln Park Zoo in Chicago. The comparison between Susie3 with the previous gorilla genome assembly (gorGor3), this new assembly (Susie3) contigs decreased 96% contigs refers to a short sequence may lack information about its location in the genome.
Similarly, the authors say, for gorGor3 genome sequence 433 861 blank, they have filled 94%. To better understand the genetic variation in these species, the team used a short read sequences from six other Western lowland gorillas. The Susie3 and compare the human genome assembly revealed a total of 117 512 and 697 insertion and deletion mutant inversion. These events have more than 86% of previously undiscovered.
The result of our species and our non-genetic variation between human cousins provide a better understanding, but also demonstrates to other mammalian genome sequencing more accurate method.
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