Single-cell technology is expected to cure cancer

Targeted therapy can block tumor growth pathway, but these cells are often able to take a detour and develop resistance to drugs. Caltech research team recently used single-cell analysis to fully draw the circuitous route of cancer. The study was published in the journal Cancer Cell on April 11th, providing precious information for developing more effective combination therapies.

Studies have shown that single cells phosphoproteomics technology can reflect the internal activities of individual cancer cells and signal transduction. "We see the growth of cancer cells to other path, you can find ways to put them all blocked," the article's corresponding author, Caltech James Heath said.

Glioblastoma is the most lethal kind of brain tumor. Although it has been developed for cancer mutations targeted therapies, but their effect is usually very short. Combination therapy targets while more mutations may be better ways to combat this disease. Heath and his colleagues conducted in-depth study of glioblastoma tissue obtained by surgery. They found that glioblastoma within 48 hours of drug targets mTOR pathway produces resistance.

Research indicates that before we found any clinical change, glioblastoma began to grow again choose the path, to find ways to circumvent the anti-cancer drugs. Single cell phosphoproteomics technology can help people to develop a more effective combination therapy of glioblastoma. The technology for personalized treatment of other cancers also makes sense, such as analysis of melanoma cells to BRAF inhibitor resistance.

Researchers University of Houston and Huazhong University of Science and Technology published an article in the journal PNAS, demonstrating a single-cell research in nanotechnology for people. They use magnetic carbon nanotubes to extract biological molecules from living cells. This nano materials can be slipped into the cell molecules smuggled out, it had no effect on cell viability. Researchers can use this technology to extract information from a single cell basis.

Zhejiang University and Harvard University researchers on the embryonic stem cells were single-cell mRNA-seq analysis. They found that these cells exhibit heterogeneity is caused by serum-free culture. The researchers identified a high degree of variability in which the gene cluster, and a unique chromatin state. The study, published in the journal Cell Reports, 80 Zhejiang University professor Guo Ji, etc. is corresponding author of this article.

In recent years, single-cell sequencing technology is developing very rapidly and widely used in epigenetic research. Scientists recently wrote a detailed description of the genetics of unicellular apparent in some key technologies. These technologies can help us detect the epigenetic modification of DNA, histones, and chromatin level in a single cell.

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